期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.703326
关键词
NAADP; HN1L; JPT2; ryanodine receptor; two-pore channel; calcium signaling
类别
资金
- Deutsche Forschungsgemeinschaft (DFG) [335447717, SFB1328]
- NCL-Foundation (Hamburg)
- EU project [INTEGRATA - DLV-813284]
- NIH [R15-GM131129]
- Joa)chim-Herz-Foundation (Hamburg)
Nicotinic acid adenine dinucleotide 2'-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores. The identity of the NAADP receptor remains unknown, but recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for modulating Ca2+ channels. This suggests that NAADP may act as a trigger for Ca2+ signaling in cells.
Nicotinic acid adenine dinucleotide 2'-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca2+ from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca2+ signal that is then amplified by other Ca2+ release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca2+ channels.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据