4.8 Review

Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions

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Summary: Adipose tissue secretes adipokines which affect metabolic processes and immune diseases like psoriasis in obese individuals. Leptin levels are closely related to obesity and exacerbate it through leptin resistance. In psoriatic patients, leptin induction is mainly driven by the IL-23/Th 17 pathway.

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