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CD58 Immunobiology at a Glance

期刊

FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.705260

关键词

CD58; lymphocyte functional antigen-3; LFA-3; CD2; T cell activation; immune evasion

资金

  1. National Natural Science Foundation of China [81872501, 81673023, 81272573, 81502068]
  2. Beijing Natural Science Foundation [7172177]

向作者/读者索取更多资源

CD58 glycoprotein is a costimulatory receptor widely distributed on human tissue cells, which interacts with its ligand CD2 to activate and proliferate T/NK cells, as well as promote cell adhesion and recognition. Soluble CD58 plays a crucial role in immunosuppression and tumor microenvironment.
The glycoprotein CD58, also known as lymphocyte-function antigen 3 (LFA-3), is a costimulatory receptor distributed on a broad range of human tissue cells. Its natural ligand CD2 is primarily expressed on the surface of T/NK cells. The CD2-CD58 interaction is an important component of the immunological synapse (IS) that induces activation and proliferation of T/NK cells and triggers a series of intracellular signaling in T/NK cells and target cells, respectively, in addition to promoting cell adhesion and recognition. Furthermore, a soluble form of CD58 (sCD58) is also present in cellular supernatant in vitro and in local tissues in vivo. The sCD58 is involved in T/NK cell-mediated immune responses as an immunosuppressive factor by affecting CD2-CD58 interaction. Altered accumulation of sCD58 may lead to immunosuppression of T/NK cells in the tumor microenvironment, allowing sCD58 as a novel immunotherapeutic target. Recently, the crucial roles of costimulatory molecule CD58 in immunomodulation seem to be reattracting the interests of investigators. In particular, the CD2-CD58 interaction is involved in the regulation of antiviral responses, inflammatory responses in autoimmune diseases, immune rejection of transplantation, and immune evasion of tumor cells. In this review, we provide a comprehensive summary of CD58 immunobiology.

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