期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.662307
关键词
leprosy; skin cells; IFN-gamma; CXCL-10; multidrug therapy
类别
资金
- CAPES
- FAPERJ
- CNPq
- National Council for Scientific and Technological Development (CNPq) [303834/2017-0]
- Rio de Janeiro Carlos Chagas Filho Research Foundation (FAPERJ) [E-26/010.002231/2019]
The study evaluated the effect of multidrug therapy on skin cell phenotype and Mycobacterium leprae-specific immune response in multibacillary leprosy cases, indicating that CXCL10 (IP-10) could be a good marker for monitoring treatment efficacy.
The treatment of multibacillary cases of leprosy with multidrug therapy (MDT) comprises 12 doses of a combination of rifampicin, dapsone and clofazimine. Previous studies have described the immunological phenotypic pattern in skin lesions in multibacillary patients. Here, we evaluated the effect of MDT on skin cell phenotype and on the Mycobacterium leprae-specific immune response. An analysis of skin cell phenotype demonstrated a significant decrease in MRS1 (SR-A), CXCL10 (IP-10) and IFNG (IFN-gamma) gene and protein expression after MDT release. Patients were randomized according to whether they experienced a reduction in bacillary load after MDT. A reduction in CXCL10 (IP-10) in sera was associated with the absence of a reduction in the bacillary load at release. Although IFN-gamma production in response to M. leprae was not affected by MDT, CXCL10 (IP-10) levels in response to M. leprae increased in cells from patients who experienced a reduction in bacillary load after treatment. Together, our results suggest that CXCL10 (IP-10) may be a good marker for monitoring treatment efficacy in multibacillary patients.
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