期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.684496
关键词
acute kidney injury; mesenchymal stem cell; extracellular vesicle; cytokine; tubular epithelial cell
类别
资金
- Research Funds of Shanghai Municipal Health Commission [2019ZB0105]
- Natural Science Foundation of Shanghai [20ZR1411100]
- Program of Shanghai Academic/Technology Research Leader [20XD1421000]
- National Natural Science Foundation of China [82070085]
- Clinical Research Funds of Zhongshan Hospital [2020ZSLC38, 2020ZSLC27]
- Smart Medical Care of Zhongshan Hospital [2020ZHZS01]
AKI is a common and life-threatening disease that can progress to chronic kidney disease or end-stage renal disease if left uncontrolled. MSCs and MSC-EVs are promising cell sources for treating AKI, with lower immunogenicity and easier storage.
Acute kidney injury (AKI) is a common and potential life-threatening disease in patients admitted to hospital, affecting 10%-15% of all hospitalizations and around 50% of patients in the intensive care unit. Severe, recurrent, and uncontrolled AKI may progress to chronic kidney disease or end-stage renal disease. AKI thus requires more efficient, specific therapies, rather than just supportive therapy. Mesenchymal stem cells (MSCs) are considered to be promising cells for cellular therapy because of their ease of harvesting, low immunogenicity, and ability to expand in vitro. Recent research indicated that the main therapeutic effects of MSCs were mediated by MSC-derived extracellular vesicles (MSC-EVs). Furthermore, compared with MSCs, MSC-EVs have lower immunogenicity, easier storage, no tumorigenesis, and the potential to be artificially modified. We reviewed the therapeutic mechanism of MSCs and MSC-EVs in AKI, and considered recent research on how to improve the efficacy of MSC-EVs in AKI. We also summarized and analyzed the potential and limitations of EVs for the treatment of AKI to provide ideas for future clinical trials and the clinical application of MSC-EVs in AKI.
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