期刊
FRONTIERS IN IMMUNOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2021.683440
关键词
immunopathogenesis; SARS-CoV-2; COVID-19; pregnant; vaccine
类别
资金
- National Science and Technology Pillar Program of China during the Twelfth Five-Year Plan Period [2014BAI05B05]
- National Clinical Research Center for Obstetrics and Gynecology [2015BAI13B05]
- National Natural Science Foundation of China [81672085, 81372804, 81873843]
- Chinese Medical Association of Clinical Medicine special funds for scientific research projects [17020400709]
- Fundamental Research Funds for the Central Universities [2017KFYXJJ102, 2019KFYXKJC053]
- Hubei Provincial Natural Science Foundation of China [2019CFA062]
- Chinese Academy of Sciences [FIRMSCOV05]
- Ferring Pharmaceuticals
- Strategic Collaborative Research Program of the Ferring Institute of Reproductive Medicine
This review analyzes the unique immunological characteristics of pregnant women and reviews their known outcomes at different trimesters from the perspective of underlying mechanisms that have been studied and speculated so far.
Since December 2019, Wuhan, China, has experienced an outbreak of coronavirus disease (COVID-19), which is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Pregnant women are deductively considered to be in immunosuppressive condition for the safety of semi-allograft fetuses, which increases the risk of being infected by the virus. In this review, we analyzed the unique immunological characteristics of pregnant women and reviewed their known outcomes at different trimesters from the perspective of underlying mechanisms that have been studied and speculated so far.
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