期刊
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
卷 12, 期 5, 页码 1285-1292出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-021-01035-z
关键词
Tumor homing peptide; Drug design; Drug delivery; Cell-penetrating peptide
资金
- Department of Biotechnology [BT/PR25526/NER/95/1238/2017]
- Indian Institute of Technology Guwahati
This study developed a peptide-based drug delivery unit with a tumor homing domain chemically linked to a cell-penetrating domain, showing selective toxicity to MDA-MB-231 breast cancer cells and superior penetration in three-dimensional MDA-MB-231 tumorospheres.
A complete peptide-based drug delivery unit has been designed with a tumor homing domain chemically linked to a syndiotactic cell-penetrating domain. The designed peptides were synthesized, characterized, and tested in vitro for cellular uptake and cytotoxicity evaluation. The differential uptake, cellular internalization, negligible hemotoxicity, selective toxicity to MDA-MB-231 breast cancer cells, and the superior penetration in three-dimensional MDA-MB-231 tumorospheres confirm their utility as a promising delivery vector.
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