期刊
CRYSTALS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/cryst11070728
关键词
nanoparticle; endocytosis; nanoparticle properties
资金
- NSFC Basic Science Center Program [11988102]
- Youth Innovation Promotion Association CAS
- National Natural Science Foundation of China [11902327, 11972041]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB22040102]
NPs are widely used as drug carriers in drug delivery due to their unique physical and structural properties. The interplay of NP properties, such as size, shape, and surface functionality, plays a crucial role in determining the final drug delivery efficacy through receptor-mediated endocytosis. Understanding these interactions can greatly enhance the design of NP platforms for drug delivery.
Nanoparticles (NPs) have been widely applied as drug carriers in drug delivery, due to their unique physical and structural properties. To achieve the drug delivery purpose, receptor-mediated endocytosis is a primary explored mechanism to internalize NPs into tumor cells. During the endocytosis process, properties of NPs, including size, shape, and surface functionality, play an important role in determining the final drug delivery efficacy. Many of these NP properties have been extensively explored individually. However, the multiple NP properties naturally interplay with each other in the endocytosis process to determine the internalization efficiency together. Therefore, it is significantly important to understand the interplay of different NP properties to improve the NP's final delivery efficacy. In this review, we focus on the interplay of NPs properties on the endocytosis process to summarize the relevant experimental observations and physical mechanisms. Particularly, three different aspects are discussed in detail, including the interplay between size and shape; size and elasticity; shape and elasticity. We have summarized the most recent works and highlighted that building up systematic understandings for the complex interplay between NP properties can greatly help a better design of NP platforms for drug delivery.
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