Automatic Microscopy Analysis with Transfer Learning for Classification of Human Sperm

Infertility is a global problem that affects many couples. Sperm analysis plays an essential role in the clinical diagnosis of human fertility. The examination of sperm morphology is an essential technique because sperm morphology is a proven indicator of biological functions. At present, the morphological classification of human sperm is conducted manually by medical experts. However, manual classification is laborious and highly dependent on the experience and capability of clinicians. To address these limitations, we propose a transfer learning method based on AlexNet to automatically classify the sperms into four different categories in terms of the World Health Organization (WHO) standards by analyzing their morphology. We adopt the feature extraction architecture of AlexNet as well as its pre-training parameters. Besides, we redesign the classification network by adding the Batch Normalization layers to improve the performance. The proposed method achieves an average accuracy of 96.0% and an average precision of 96.4% in the freely-available HuSHeM dataset, which exceeds the performance of previous algorithms. Our method shows that automatic sperm classification has great potential to replace manual sperm classification in the future.

Automated summary

Infertility is a global issue impacting many couples, with sperm morphology being a crucial indicator of fertility. Manual classification of sperm by medical experts is labor-intensive and reliant on their experience. By leveraging a transfer learning method based on AlexNet, automatic classification of sperm into WHO-standard categories can achieve high accuracy and precision, showing promise for future applications.