期刊
APPLIED SCIENCES-BASEL
卷 11, 期 17, 页码 -出版社
MDPI
DOI: 10.3390/app11177788
关键词
Ziziphus lotus L; (Lam; ); flavonoids; antioxidant; anti-hyperlipidemia
类别
资金
- Le Studium-Institute for Advanced Studies, Loire Valley, Orleans, France
- French government via the French Embassy in Thailand
- Campus France through the PHC SIAM (PNPIA) [44926WK]
This study evaluated the anti-hyperlipidemic and antioxidant activities of a flavonoid-rich aqueous extract of Ziziphus lotus fruits. The extract showed significant antioxidant power against DPPH radicals and beta-carotene oxidation. Additionally, it exhibited a considerable anti-hyperlipidemic effect by improving abnormal lipid profile and blood glucose levels in mice on a chronic high-fat diet.
Ziziphus lotus (L.) Lam. (Z. lotus) is a medicinal plant species that is widely distributed throughout the Mediterranean basin. Moroccans traditionally use it to treat many illnesses thanks to its beneficial medicinal properties. The purpose of this study is to assess the anti-hyperlipidemic and antioxidant activities of a flavonoid-rich aqueous extract of Z. lotus fruits (ZLF). The 2-2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay and the beta-carotene bleaching test were used to determine the antioxidant activity of ZLF. The anti-hyperlipidemic effect of the aqueous extract of ZLF (200 and 400 mg/kg) was evaluated in albino mice exposed to the chronic high-fat diet, based on lipid profile, blood sugar, and changes in growth performance. The results showed that the aqueous extract of ZLF rich in flavonoids (2242.89 +/- 25 mu g QE (quercitin equivalent)/mg), and has a considerable antioxidant power against DPPH radicals (IC50 = 116 +/- 0.02 mu g/mL) and beta-carotene oxidation. The aqueous extract of ZLF also showed a significant anti-hyperlipidemic effect by improving abnormal changes in lipid profile and blood glucose levels in albino mice exposed to a chronic high-fat diet. Our findings suggest that the anti-hyperlipidemic activities of ZLF aqueous extract are correlated with its flavonoid content and antioxidant activity. Therefore, the aqueous extract of ZLF could be an essential therapeutic candidate for hyperlipidemia patients, thanks to its richness in bioactive molecules.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据