期刊
APPLIED SCIENCES-BASEL
卷 11, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/app11125660
关键词
leaf skin of Aloe vera; mitochondrial activities; skin antiaging; lactic acid fermentation
This study demonstrates that fermenting aloe vera leaf skin with Lactobacillus plantarum enhances mitochondrial activation and reduces photo-aging of UVb-irradiated skin fibroblasts, leading to increased collagen production and decreased reactive oxygen species. The fermented extract shows synergistic effects with quercetin and bioactive substances, making it a promising anti-aging agent for skin care.
This study is the first to show that increased mitochondrial activities improved the antiaging effects of Aloe vera leaf skin fermented by Lactobacillus plantarum on UVb-irradiated skin fibroblasts. The fermented extract (AF) increased the activities of mitochondrial reductase and the complex II and significantly reduced reactive oxygen species (ROS) production, even under UVb stress conditions, and also increased DPPH free radical scavenging activities compared with the hot water extract of outer layers of aloe leaf (AW) and quercetin itself. AF exerted a synergistic effect with quercetin and bioactive substances derived from the fermentation process. Moreover, mitochondrial activation of UVb-irradiated human skin fibroblasts by 0.3% (w/v) of the AF plays important roles in increasing collagen production up to 125 +/- 5.45% and decreasing MMP-1 secretion down to 69.41 +/- 2.63% of the control levels. The AF enhanced the upregulation of collagen gene expression, and this change was also greater than those induced by the AW and quercetin. Therefore, this study concludes that fermentation of the skin of aloe leaves increases the activation of mitochondria and inhibits the photo-aging of UVb-irradiated skin fibroblasts.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据