期刊
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
卷 10, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13756-021-00994-9
关键词
Cohort care; Carbapenem resistant Enterobacteriaceae; Hospital acquired infections; Admission screening; Pediatric and neonatal care
类别
资金
- Karolinska Institute
- Swedish Foundation for International Cooperation in Research and Higher Education (STINT) [SG 2015-5972]
- Swedish research council (VR) [330-2014-6356]
- EU Marie Curie
- SIDA
Admission screening for CRE and cohort care in pediatric ICUs significantly decreased CRE acquisition, cases of HAI, and duration of hospital stay.
Objectives To assess if admission screening for Carbapenem Resistant Enterobacteriaceae (CRE) and cohort care can reduce CRE acquisition (CRE colonization during hospital stay), Hospital Acquired Infections (HAI), hospital-stay, mortality, and costs in three Intensive Care Units (ICU's) at the Vietnamese National Children's Hospital. Method CRE screening using rectal swabs and ChromIDCarbas elective culture at admission and if CRE negative, once weekly. Patients were treated in cohorts based on CRE colonization status. Results CRE colonization at baseline point-prevalence screening was 76.9% (103/134). Of 941 CRE screened at admission, 337 (35.8%) were CREpos. 694 patients met inclusion criteria. The 244 patients CRE negative at admission and screened > 2 times were stratified in 8 similar size groups (periods), based on time of admission. CRE acquisition decreased significant (OR - 3.2, p < 0.005) from 90% in period 2 (highest) to 48% in period 8 (last period). Patients with CRE acquisition compared to no CRE acquisition had a significantly higher rate of culture confirmed HAI, n = 20 (14%) vs. n = 2 (2%), longer hospital stays, 3.26 vs. 2.37 weeks, and higher total treatment costs, 2852 vs. 2295 USD. Conclusion Admission CRE screening and cohort care in pediatric ICU's significantly decreased CRE acquisition, cases of HAI and duration of hospital-stay.
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