期刊
ADVANCED SCIENCE
卷 8, 期 21, 页码 -出版社
WILEY
DOI: 10.1002/advs.202100627
关键词
cardiomyocytes; complementary metal-oxide semiconductor multielectrode arrays; metamaterials; microelectrode arrays; neurons; plasmonic optical stimulation; plasmonics
资金
- European Research Council under the European Union's Horizon 2020 Programme/ERC Grant [862078]
- European Research Council (ERC) [862078] Funding Source: European Research Council (ERC)
Optical stimulation technologies are gaining importance in cardiology, neuroscience studies, and drug discovery pathways, providing high spatial-temporal resolution control over cell activity. Plasmonic metamaterials can be used to elicit action potentials by converting near infrared laser pulses into stimulatory currents, allowing for direct stimulation of cardiomyocytes and neurons on commercial microelectrode arrays.
Optical stimulation technologies are gaining great consideration in cardiology, neuroscience studies, and drug discovery pathways by providing control over cell activity with high spatio-temporal resolution. However, this high precision requires manipulation of biological processes at genetic level concealing its development from broad scale application. Therefore, translating these technologies into tools for medical or pharmacological applications remains a challenge. Here, an all-optical nongenetic method for the modulation of electrogenic cells is introduced. It is demonstrated that plasmonic metamaterials can be used to elicit action potentials by converting near infrared laser pulses into stimulatory currents. The suggested approach allows for the stimulation of cardiomyocytes and neurons directly on commercial complementary metal-oxide semiconductor microelectrode arrays coupled with ultrafast pulsed laser, providing both stimulation and network-level recordings on the same device.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据