期刊
ADVANCED SCIENCE
卷 8, 期 18, 页码 -出版社
WILEY
DOI: 10.1002/advs.202100293
关键词
chronic wounds; glycosaminoglycans; hydrogels; wound healing
资金
- German Research Council (DFG) [SFB-TR67]
Excessive inflammation can hinder chronic wound healing. A composite wound contact layer with selective sequestering ability for pro-inflammatory chemokines was developed by manipulating the affinity profile of the hydrogel component. Testing in a porcine model showed that this treatment could dampen inflammatory signals while promoting healing.
Excessive inflammation often impedes the healing of chronic wounds. Scavenging of chemokines by multiarmed poly(ethylene glycol)-glycosaminoglycan (starPEG-GAG) hydrogels has recently been shown to support regeneration in a diabetic mouse chronic skin wound model. Herein, a textile-starPEG-GAG composite wound contact layer (WCL) capable of selectively sequestering pro-inflammatory chemokines is reported. Systematic variation of the local and integral charge densities of the starPEG-GAG hydrogel component allows for tailoring its affinity profile for biomolecular signals of the wound milieu. The composite WCL is subsequently tested in a large animal (porcine) model of human wound healing disorders. Dampening excessive inflammatory signals without affecting the levels of pro-regenerative growth factors, the starPEG-GAG hydrogel-based WCL treatment induced healing with increased granulation tissue formation, angiogenesis, and deposition of connective tissue (collagen fibers). Thus, this biomaterials technology expands the scope of a new anti-inflammatory therapy toward clinical use.
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