期刊
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS
卷 77, 期 -, 页码 275-285出版社
INT UNION CRYSTALLOGRAPHY
DOI: 10.1107/S2053230X21007470
关键词
bacterial microcompartments; bacterial organelles; BMC; shell proteins; choline; glycyl radicals
资金
- National Institutes of Health, National Institute of Allergy and Infectious Diseases [R01AI081146]
- US Department of Energy, Office of Science [DE-FC02-02ER63421]
This study reports the structures of six hexameric shell proteins from type I and type II choline-utilization microcompartments, revealing shared electrostatic surface properties among the four types of shell proteins described.
Bacterial microcompartments are large supramolecular structures comprising an outer proteinaceous shell that encapsulates various enzymes in order to optimize metabolic processes. The outer shells of bacterial microcompartments are made of several thousand protein subunits, generally forming hexameric building blocks based on the canonical bacterial microcompartment (BMC) domain. Among the diverse metabolic types of bacterial microcompartments, the structures of those that use glycyl radical enzymes to metabolize choline have not been adequately characterized. Here, six structures of hexameric shell proteins from type I and type II choline-utilization microcompartments are reported. Sequence and structure analysis reveals electrostatic surface properties that are shared between the four types of shell proteins described here.
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