相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Benedict-Tilman Berger et al.
CELL CHEMICAL BIOLOGY (2021)
Correlating Drug-Target Residence Time and Post-antibiotic Effect: Insight into Target Vulnerability
Shabnam Davoodi et al.
ACS INFECTIOUS DISEASES (2020)
Pharmacokinetic-pharmacodynamic models that incorporate drug-target binding kinetics
Fereidoon Daryaee et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2019)
Targeted protein degradation: expanding the toolbox
Matthieu Schapira et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Escherichia coli Modulates Proteolysis of LpxC
Nikolas Thomanek et al.
FRONTIERS IN MICROBIOLOGY (2019)
Identification of long-lived synaptic proteins by proteomic analysis of synaptosome protein turnover
Seok Heo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Binding Kinetics Survey of the Drugged Kinome
Victoria Georgi et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
Drug-Target Kinetics in Drug Discovery
Peter J. Tonge
ACS CHEMICAL NEUROSCIENCE (2018)
Correlating drug-target kinetics and in vivo pharmacodynamics: long residence time inhibitors of the FabI enoyl-ACP reductase
Fereidoon Daryaee et al.
CHEMICAL SCIENCE (2016)
A [32P]NAD+-based method to identify and quantitate long residence time enoyl-acyl carrier protein reductase inhibitors
Weixuan Yu et al.
ANALYTICAL BIOCHEMISTRY (2015)
Translating slow-binding inhibition kinetics into cellular and in vivo effects
Grant K. Walkup et al.
NATURE CHEMICAL BIOLOGY (2015)
ESKAPEing the labyrinth of antibacterial discovery
Ruben Tommasi et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Accurate Protein Complex Retrieval by Affinity Enrichment Mass Spectrometry (AE-MS) Rather than Affinity Purification Mass Spectrometry (AP-MS)
Eva C. Keilhauer et al.
MOLECULAR & CELLULAR PROTEOMICS (2015)
FtsH-Mediated Coordination of Lipopolysaccharide Biosynthesis in Escherichia coli Correlates with the Growth Rate and the Alarmone (p)ppGpp
Michael Schaekermann et al.
JOURNAL OF BACTERIOLOGY (2013)
Global Dynamics of the Escherichia coli Proteome and Phosphoproteome During Growth in Minimal Medium
Nelson C. Soares et al.
JOURNAL OF PROTEOME RESEARCH (2013)
Native SILAC: Metabolic Labeling of Proteins in Prototroph Microorganisms Based on Lysine Synthesis Regulation
Florian Froehlich et al.
MOLECULAR & CELLULAR PROTEOMICS (2013)
Pyridone Methylsulfone Hydroxamate LpxC Inhibitors for the Treatment of Serious Gram-Negative Infections
Justin I. Montgomery et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
The Influence of Receptor Kinetics on the Onset and Duration of Action and the Therapeutic Index of NVA237 and Tiotropium
David A. Sykes et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Challenges of Antibacterial Discovery
Lynn L. Silver
CLINICAL MICROBIOLOGY REVIEWS (2011)
Control of Lipopolysaccharide Biosynthesis by FtsH-Mediated Proteolysis of LpxC Is Conserved in Enterobacteria but Not in All Gram-Negative Bacteria
Sina Langklotz et al.
JOURNAL OF BACTERIOLOGY (2011)
The resurgence of covalent drugs
Juswinder Singh et al.
NATURE REVIEWS DRUG DISCOVERY (2011)
Depletion of antibiotic targets has widely varying effects on growth
Jun-Rong Wei et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) Applied to Quantitative Proteomics of Bacillus subtilis
Boumediene Soufi et al.
JOURNAL OF PROTEOME RESEARCH (2010)
Delineating Bacteriostatic and Bactericidal Targets in Mycobacteria Using IPTG Inducible Antisense Expression
Parvinder Kaur et al.
PLOS ONE (2009)
Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli
Adam W. Barb et al.
BIOCHEMISTRY (2007)
Drugs for bad bugs: confronting the challenges of antibacterial discovery
David J. Payne et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Opinion - Drug-target residence time and its implications for lead optimization
Robert A. Copeland et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
The C-terminal end of LpxC is required for degradation by the FtsH protease
F Führer et al.
MOLECULAR MICROBIOLOGY (2006)
A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid a biosynthesis with antibiotic activity comparable to ciprofloxacin
AL McClerren et al.
BIOCHEMISTRY (2005)
Clinical relevance of bacteriostatic versus bactericidal mechanisms of action in the treatment of gram-positive bacterial infections
GA Pankey et al.
CLINICAL INFECTIOUS DISEASES (2004)
Synthesis/degradation ratio mass spectrometry for measuring relative dynamic protein turnover
BJ Cargile et al.
ANALYTICAL CHEMISTRY (2004)
Crystal structure of LpxC, a zinc-dependent deacetylase essential for endotoxin biosynthesis
DA Whittington et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Dynamics of protein turnover, a missing dimension in proteomics
JM Pratt et al.
MOLECULAR & CELLULAR PROTEOMICS (2002)
Antibacterial activities and characterization of novel inhibitors of LpxC
JM Clements et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)