期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 7, 期 9, 页码 4446-4453出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c00946
关键词
nanomaterials; intranasal delivery; cytokine; autoimmune disease; multiple sclerosis
资金
- Korea Ministry of Health and Welfare [HI17C0076]
- National Research Foundation (NRF) of Korea [2019R1A2C2004765]
- National Research Foundation of Korea [2019R1A2C2004765] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study demonstrates the therapeutic potential of IL-13-loaded XL-MSNs for MS patients by stabilizing cytokine delivery to the central nervous system and improving symptoms.
Multiple sclerosis (MS) treatment via cytokine-mediated immunomodulation has been hampered by the difficulty with which cytokines can be stably and noninvasively delivered to the central nervous system. Here, we show that interleukin (IL)-13 packaged in extra-large-pore mesoporous silica nanoparticles (XL-MSNs) is protected from degradation and directs the alternative activation of macrophages both in vitro and in vivo. Furthermore, the noninvasive intranasal delivery of IL-13-loaded XL-MSNs ameliorated the symptoms of experimental autoimmune encephalomyelitis, a murine model of MS, accompanied by the induction of chemokines orchestrating immune cell infiltration. These results demonstrate the therapeutic potential of IL-13-loaded XL-MSNs for MS patients.
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