Challenging the pipeline

This commentary presents a thought experiment seeking to answer the key question: ``If you were to put aside all the traditional drug discovery processes and start a new drug discovery program that places the highest priority on human and disease-relevant models throughout the entire process, how could it be done?''

Automated summary

This commentary presents a thought experiment on starting a new drug discovery program that prioritizes human and disease-relevant models throughout the entire process, challenging traditional methods in the field.