期刊
OPHTHALMIC SURGERY LASERS & IMAGING RETINA
卷 52, 期 6, 页码 319-326出版社
SLACK INC
DOI: 10.3928/23258160-20210528-04
关键词
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资金
- Research to Prevent Blindness (New York, New York)
- NIH Center Core Grant (Bethesda, Maryland) [P30EY014801]
The incidence of infectious endophthalmitis after intravitreal anti-VEGF injections remains low between 2018 and 2020, similar to prior reports.
BACKGROUND AND OBJECTIVE: To report the incidence and clinical features of infectious endophthalmitis after intravitreal (IV) injection of anti-vascular endothelial growth factor inhibitors (VEGF) between 2018 and 2020 and to compare to prior rates. PATIENTS AND METHODS: Retrospective analysis of patients with endophthalmitis after anti-VEGF IV injections treated at Bascom Palmer Eye Institute between January 1, 2018, and December 31, 2020. RESULTS: Between 2018 and 2020, the rate of clinically diagnosed endophthalmitis was 0.014% (10/71,858) and of culture-positive was 0.008% (6/71,858). Clinically diagnosed endophthalmitis rates per injection were: aflibercept (0.022%); ranibizumab (0.019%); bevacizumab (0%); and brolucizumab (0%). Clinically diagnosed endophthalmitis rates were similar in the present study compared to those from 2005 to 2017 (P =.84). Fifteen eyes were diagnosed with endophthalmitis (10 in-house, five external referrals). Of culture-positive eyes, the organisms were coagulase-negative Staphylococcus (8/11), Streptococcus species (2/11), and Abiotrophia defectiva (1/11). A universal face-masking policy in 2020 did not lower infection rates (P =.73). CONCLUSION: Endophthalmitis rates after IV anti-VEGF remain low and are similar to prior reports.
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