期刊
NANOMATERIALS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/nano11061507
关键词
Ti-based alloy; ion etching; nano-topography; biocompatibility; biomedical implants
类别
资金
- Technology Innovation Program (material parts package business) - Ministry of Trade, Industry, and Energy (MOTIE, Korea) [20001221]
- Korea Evaluation Institute of Industrial Technology (KEIT) [20001221] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [5199990514442, 4120200513611] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The nano-topographical features of titanium-niobium-zirconium (TNZ) alloy surfaces were successfully controlled using the target-ion induced plasma sputtering (TIPS) technique. Various nanopatterns were fabricated on the surface of the TNZ alloys, with experimental groups showing superior biological functions when nanopattern widths were >= 130 nm.
Nano-scale surface roughening of metallic bio-implants plays an important role in the clinical success of hard tissue reconstruction and replacement. In this study, the nano-topographical features of titanium-niobium-zirconium (TNZ) alloy surfaces were controlled by using the target-ion induced plasma sputtering (TIPS) technique to improve the in vitro osteoblastic response. The TIPS technique is a novel strategy for etching the surface of metallic bio-implants using bombardment of target metal cations, which were accelerated by an extremely high negative bias voltage applied to the substrates. The nano-topography of the TNZ surfaces was successfully controlled by modulating experimental variables (such as the ion etching energy and the type of substrate or target materials) of TIPS. As a result, various nanopatterns (size: 10-210 nm) were fabricated on the surface of the TNZ alloys. Compared with the control group, experimental groups with nanopattern widths of >= 130 nm (130 and 210 nm groups) exhibited superior cell adhesion, proliferation, and differentiation. Our findings demonstrate that TIPS is a promising technology that can impart excellent biological functions to the surface of metallic bio-implants.
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