期刊
NANOMATERIALS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nano11092178
关键词
hydrogel; nanofibers; skin cover; alginate; polyvinyl alcohol
类别
资金
- Ministry of Education, Youth and Sports of the Czech Republic
- European Union via European Structural and Investment Funds as part of the Research, Development and Education Operational Programme-Hybrid Materials for Hierarchical Structures project (HyHi) [CZ.02.1.01/0.0/0.0/16_019/0000843]
- project of the university research grant-Research of nanofibrous materials for the treatment of glaucoma disease [TUL: PURE-2021-6005]
The study focused on producing a hydrogel nanofiber skin cover, by fabricating fibrous layers with enhanced mechanical properties which were found to be non-cytotoxic during application.
The study addressed the production of a hydrogel nanofiber skin cover and included the fabrication of hydrogel nanofibers from a blend of polyvinyl alcohol and alginate. The resulting fibrous layer was then crosslinked with glutaraldehyde, and, after 4 h of crosslinking, although the gelling component, i.e., the alginate, crosslinked, the polyvinyl alcohol failed to do so. The experiment included the comparison of the strength and ductility of the layers before and after crosslinking. It was determined that the fibrous layer following crosslinking evinced enhanced mechanical properties, which acted to facilitate the handling of the material during its application. The subsequent testing procedure proved that the fibrous layer was not cytotoxic. The study further led to the production of a modified hydrogel nanofiber layer that combined polyvinyl alcohol with alginate and albumin. The investigation of the fibrous layers produced determined that following contact with water the polyvinyl alcohol dissolved leading to the release of the albumin accompanied by the swelling of the alginate and the formation of a hydrogel.
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