期刊
NANOMATERIALS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nano11092352
关键词
regenerated silk; exfoliated graphite; tannin extracts; mechanical properties; adhesion; biocompatibility
类别
资金
- Italian Ministry of Education, University and Research (MIUR) under the PRIN Project Development and promotion of the Levulinic acid and Carboxylate platforms by the formulation of novel and advanced PHA-based biomaterials and their exploitation for 3D pr [2017FWC3WC]
- FONDAZIONE CARIT BANDO [1/2020]
The study reports the development of bio-glues obtained by blending regenerated silk with a soluble plant-derived polyphenol, which exhibit outstanding stretchability and high shear strength, suitable for biomedical and bioelectronics applications.
The development of bio-glues is still a challenging task, regarding adhesion on wet surfaces; often, high performance and adaption to complex geometries need to be combined in one material. Here, we report biocompatible adhesives obtained by blending regenerated silk (RS) with a soluble plant-derived polyphenol (i.e., chestnut tannin) that was also used to exfoliate graphite to obtain graphene-based RS/tannin (G-RS/T) composites. The resultant G-RS/T hybrid material exhibited outstanding stretchability (i.e., 400%) and high shear strength (i.e., 180 kPa), superior to that of commercial bio-glues, and showed sealant properties for tissue approximation. Moreover, we showed how such nanocomposites exhibit electromechanical properties that could potentially be used for the realization of green and eco-friendly piezoelectric devices. Finally, we demonstrate the in vitro glue's biocompatibility and anti-oxidant properties that enable their utilization in clinical applications.
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