期刊
NANOMATERIALS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nano11092267
关键词
iron oxide nanoparticles; magnetoferritin; magnetogenetics; remote particle manipulation
类别
资金
- Deutsche Forschungsgemeinschaft (DFG) [SFB1208]
- 'Freigeist fellowship' of VolkswagenFoundation
- Fonds der Chemischen Industrie
- State of North Rhine-Westphalia [INST 208/749-1 FUGG]
- DFG [INST 208/749-1 FUGG]
The properties of two different types of magnetic nanoparticles were investigated and their potential for biomedical applications was assessed. The study confirmed their biocompatibility in a living cell environment and found that magnetoferritin exhibited a higher magnetic force response inside cells compared to 'nanoflower' nanoparticles.
Magnetic nanoparticles (MNPs) are widely known as valuable agents for biomedical applications. Recently, MNPs were further suggested to be used for a remote and non-invasive manipulation, where their spatial redistribution or force response in a magnetic field provides a fine-tunable stimulus to a cell. Here, we investigated the properties of two different MNPs and assessed their suitability for spatio-mechanical manipulations: semisynthetic magnetoferritin nanoparticles and fully synthetic 'nanoflower'-shaped iron oxide nanoparticles. As well as confirming their monodispersity in terms of structure, surface potential, and magnetic response, we monitored the MNP performance in a living cell environment using fluorescence microscopy and asserted their biocompatibility. We then demonstrated facilitated spatial redistribution of magnetoferritin compared to 'nanoflower'-NPs after microinjection, and a higher magnetic force response of these NPs compared to magnetoferritin inside a cell. Our remote manipulation assays present these tailored magnetic materials as suitable agents for applications in magnetogenetics, biomedicine, or nanomaterial research.
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