期刊
NANOMATERIALS
卷 11, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/nano11092324
关键词
photodynamic therapy; cancer treatment; cell death mechanisms; melanoma; nanomedicine
类别
资金
- National Science Foundation EAGER-NSF [1835688]
- UNC Research Opportunities Initiative
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1835688] Funding Source: National Science Foundation
The use of nanoparticle-based materials in photodynamic therapy for cancer treatment is a growing area of research, with Polysilsesquioxane nanoparticles showing promise in enhancing PDT effectiveness. This study focused on a Protroporphyrin IX-based PSilQ platform, revealing that cell death pathways during PDT were regulated by both apoptosis and ferroptosis.
The use of nanoparticle-based materials to improve the efficacy of photodynamic therapy (PDT) to treat cancer has been a burgeoning field of research in recent years. Polysilsesquioxane (PSilQ) nanoparticles with remarkable features, such as high loading of photosensitizers, biodegradability, surface tunability, and biocompatibility, have been used for the treatment of cancer in vitro and in vivo using PDT. The PSilQ platform typically shows an enhanced PDT performance following a cell death mechanism similar to the parent photosensitizer. Ferroptosis is a new cell death mechanism recently associated with PDT that has not been investigated using PSilQ nanoparticles. Herein, we synthesized a protoporphyrin IX (PpIX)-based PSilQ platform (PpIX-PSilQ NPs) to study the cell death pathways, with special focus on ferroptosis, during PDT in vitro. Our data obtained from different assays that analyzed Annexin V binding, glutathione peroxidase activity, and lipid peroxidation demonstrate that the cell death in PDT using PpIX-PSilQ NPs is regulated by apoptosis and ferroptosis. These results can provide alternative approaches in designing PDT strategies to enhance therapeutic response in conditions stymied by apoptosis resistance.
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