期刊
MOLECULAR THERAPY-NUCLEIC ACIDS
卷 26, 期 -, 页码 649-664出版社
CELL PRESS
DOI: 10.1016/j.omtn.2021.08.029
关键词
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资金
- National Natural Science Foundation of China [81872392, 82073254]
- Scientific Research Foundation for Introduced High-Level Personnel in Chongqing Medical University [41021300160256]
- Chongqing Talents-Exceptional Young Talents Project [CQYC202005044]
- Science and technology research project of Chongqing Municipal Education Commission [KJZD-K202100405]
- National Program on Key Basic Research Project (973 Program) [2009CB522606]
- National Science and Technology Major Projects for Major New Drugs Innovation and Development [2008ZX09101-033]
The study revealed that circ-TNPO3 plays a crucial inhibitory role in gastric cancer by regulating the MYC-SNAIL pathway to suppress proliferation and metastasis.
Gastric cancer (GC) continues to be the most common gastrointestinal malignancy in China, and tumor metastases are a major reason for poor prognosis. Circular RNAs (circRNAs) are an intriguing type of noncoding RNAs with important regulatory roles. However, the roles of circRNAs in GC metastasis have not been fully elucidated. Here, we reported that circ-transportin 3 (TNPO3) was significantly downregulated in 103 pairs of GC tissues compared with matched noncancerous tissues. The level of circ-TNPO3 expression correlated with differentiation of GC, and plasma circ-TNPO3 could serve as a potential diagnostic biomarker. Functionally, circ-TNPO3 inhibited proliferation and migration of GC in vitro and in vivo. We further verified that circTNPO3 competitively interacted with insulin-like growth role of IGF2BP3 in stabilizing MYC mRNA was weakened, which inhibited the expression of MYC and its target SNAIL. Taken together, circ-TNPO3 acts as a protein decoy for IGF2BP3 to regulate the MYC-SNAIL axis, thereby suppressing the proliferation and metastasis of GC. Therefore, circfor GC.
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