期刊
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
卷 -, 期 172, 页码 -出版社
JOURNAL OF VISUALIZED EXPERIMENTS
DOI: 10.3791/62491
关键词
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资金
- European Community [653706, 871037]
- Region Auvergne-Rhone-Alpes through the Booster programme
EMBL Grenoble operates the High Throughput Crystallization Laboratory (HTX Lab) offering crystallography services and developing fully automated pipelines for macromolecular crystallography, including protein-to-structure, protein-ligand complex characterization, and fragment screening pipelines that can be remotely operated over the internet.
EMBL Grenoble operates the High Throughput Crystallization Laboratory (HTX Lab), a large-scale user facility offering high throughput crystallography services to users worldwide. The HTX lab has a strong focus in the development of new methods in macromolecular crystallography. Through the combination of a high throughput crystallization platform, the CrystalDirect technology for fully automated crystal mounting and cryocooling and the CRIMS software we have developed fully automated pipelines for macromolecular crystallography that can be remotely operated over the internet. These include a protein-to-structure pipeline for the determination of new structures, a pipeline for the rapid characterization of protein-ligand complexes in support of medicinal chemistry, and a large-scale, automated fragment screening pipeline enabling evaluation of libraries of over 1000 fragments. Here we describe how to access and use these resources.
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