4.2 Article

Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteins

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Editorial Material Medicine, General & Internal

Oxford-AstraZeneca COVID-19 vaccine efficacy

Maria Deloria Knoll et al.

LANCET (2021)

Article Medicine, General & Internal

Interim Results of a Phase 1-2a Trial of Ad26.COV2.S Covid-19 Vaccine

J. Sadoff et al.

Summary: The study conducted a multicenter, placebo-controlled, phase 1-2a trial, with participants randomly assigned to receive the Ad26.COV2.S vaccine. The results showed that the safety and immunogenicity profiles of the vaccine support further development.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics

Monica C. Pillon et al.

Summary: Nsp15 is a uridine specific endoribonuclease present in all coronaviruses. The cryo-EM structures of SARS-CoV-2 Nsp15 in the apo and UTP-bound states, together with biochemical experiments, mass spectrometry, and molecular dynamics simulations, provide insights into the catalytic mechanism of Nsp15 and its conformational dynamics.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Structural characterization of nonstructural protein 1 from SARS-CoV-2

Cameron Semper et al.

Summary: The crystal structure of the globular domain of SARS-CoV-2 Nsp1 reveals a six-stranded, capped beta-barrel motif and distinct structural features based on variations in amino acid sequence. Combining this high-resolution structure with existing data allows for proposing a model of the full-length protein, providing insight into a major pathogenic determinant of SARS-CoV-2.

ISCIENCE (2021)

Letter Public, Environmental & Occupational Health

AZD1222 (Covishield) vaccination for COVID-19: Experiences, challenges, and solutions in Nepal

Ranjit Sah et al.

TRAVEL MEDICINE AND INFECTIOUS DISEASE (2021)

Article Multidisciplinary Sciences

Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

Ke Zhang et al.

Summary: The research shows that the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host messenger RNA (mRNA) export receptor heterodimer NXF1-NXT1, leading to retention of cellular mRNAs in the nucleus during infection. Increasing levels of NXF1 can rescue the Nsp1-mediated mRNA export block and inhibit SARS-CoV-2 infection. Antagonizing the inhibitory function of Nsp1 on mRNA export may represent a strategy to restore proper antiviral host gene expression in infected cells.

SCIENCE ADVANCES (2021)

Article Biochemistry & Molecular Biology

Two conserved oligomer interfaces of NSP7 and NSP8 underpin the dynamic assembly of SARS-CoV-2 RdRP

Mahamaya Biswal et al.

Summary: The replication of the coronavirus genome is regulated by a complex of non-structural proteins, with NSP7 and NSP8 playing key roles. The crystal structure of the NSP7-NSP8 complex reveals a heterotetrameric form, and mutations in interface I and II affect the stability and activity of the complex. This study provides insights into the dynamic assembly of NSP7 and NSP8 in regulating viral genome replication, with implications for antiviral drug development.

NUCLEIC ACIDS RESEARCH (2021)

Article Immunology

Factors Influencing the Efficacy of COVID-19 Vaccines: A Quantitative Synthesis of Phase III Trials

Luigino Calzetta et al.

Summary: The study evaluated the efficacy of COVID-19 vaccines and potential influencing factors, finding overall positive results but some heterogeneity, with age possibly influencing mRNA-based vaccines. However, no significant modifying factors were identified overall.

VACCINES (2021)

Review Virology

Emerging coronaviruses: Genome structure, replication, and pathogenesis

Yu Chen et al.

JOURNAL OF MEDICAL VIROLOGY (2020)

Editorial Material Biotechnology & Applied Microbiology

Therapeutic options for the 2019 novel coronavirus (2019-nCoV)

Guangdi Li et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Pharmacology & Pharmacy

Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods

Canrong Wu et al.

ACTA PHARMACEUTICA SINICA B (2020)

Article Biochemistry & Molecular Biology

Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2

Youngchang Kim et al.

PROTEIN SCIENCE (2020)

Article Multidisciplinary Sciences

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Yan Gao et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Structure of replicating SARS-CoV-2 polymerase

Hauke S. Hillen et al.

NATURE (2020)

Article Multidisciplinary Sciences

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

David E. Gordon et al.

NATURE (2020)

Article Medicine, General & Internal

A Trial of Lopinavir-Ritonavir in Adults Hospitalized with Severe Covid-19

B. Cao et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Biochemistry & Molecular Biology

Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3

David N. Frick et al.

BIOCHEMISTRY (2020)

Editorial Material Pharmacology & Pharmacy

Darunavir does not prevent SARS-CoV-2 infection in HIV patients

Agostino Riva et al.

PHARMACOLOGICAL RESEARCH (2020)

Article Multidisciplinary Sciences

Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin

Petra Krafcikova et al.

NATURE COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Crystal Structure of Non-Structural Protein 10 from Severe Acute Respiratory Syndrome Coronavirus-2

Annika Rogstam et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Chemistry, Multidisciplinary

Influenza A M2 Inhibitor Binding Understood through Mechanisms of Excess Proton Stabilization and Channel Dynamics

Laura C. Watkins et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Biochemistry & Molecular Biology

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

Katharina Schubert et al.

NATURE STRUCTURAL & MOLECULAR BIOLOGY (2020)

Review Biochemistry & Molecular Biology

Structural Characterization of SARS-CoV-2: Where We Are, and Where We Need to Be

Giuseppina Mariano et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

Review Biochemistry & Molecular Biology

A systematic review of SARS-CoV-2 vaccine candidates

Yetian Dong et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Letter Biochemistry & Molecular Biology

Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design

Sheng Lin et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Article Biochemistry & Molecular Biology

Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2

Changhui Zhang et al.

MOLECULAR BIOMEDICINE (2020)

Article Pharmacology & Pharmacy

Discovering drugs to treat coronavirus disease 2019 (COVID-19)

Liying Dong et al.

DRUG DISCOVERIES AND THERAPEUTICS (2020)

Article Biochemistry & Molecular Biology

Predicting commercially available antiviral drugs that may act on the novel coronavirus (SARS-CoV-2) through a drug-target interaction deep learning model

Bo Ram Beck et al.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2020)

Article Multidisciplinary Sciences

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

Robert N. Kirchdoerfer et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

Inhibition of the precursor and mature forms of HIV-1 protease as a tool for drug evaluation

Jana Humpolickova et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

GASS-WEB: a web server for identifying enzyme active sites based on genetic algorithms

Joao P. A. Moraes et al.

NUCLEIC ACIDS RESEARCH (2017)

Article Multidisciplinary Sciences

Structural basis and functional analysis of the SARS coronavirus nsp14-nsp10 complex

Yuanyuan Ma et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Multidisciplinary Sciences

HIV-1 Protease Dimerization Dynamics Reveals a Transient Druggable Binding Pocket at the Interface

Fabio Pietrucci et al.

SCIENTIFIC REPORTS (2015)

Review Virology

HIV-1 Protease: Structural Perspectives on Drug Resistance

Irene T. Weber et al.

VIRUSES-BASEL (2009)