Emerging Role of microRNAs and Long Non-Coding RNAs in Sjogren's Syndrome

Sjogren's Syndrome (SS) is a chronic autoimmune inflammatory disease. It is considered a multifactorial pathology, in which underlying genetic predisposition, epigenetic mechanisms and environmental factors contribute to development. The epigenetic regulations represent a link between genetic predisposition and environmental factors. Recent studies suggested a regulatory role for non-coding RNAs in critical biological and disease processes. Among non-coding RNAs, microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) play a critical role in the post-transcriptional mRNA expression, forming a complex network of gene expression regulation. This review aims to give an overview of the latest studies that have investigated the role of miRNAs and lncRNAs in the SS. We included papers that investigated the expression of non-coding RNAs on different tissues, in particular on peripheral blood mononuclear cells and salivary glands. However, regarding the involvement of non-coding RNAs genetic variability in SS susceptibility very few data are available. Further research could help to elucidate underlying pathogenic processes of SS and provide new opportunities for the development of targeted therapies.

Automated summary

Sjogren's Syndrome is a chronic autoimmune inflammatory disease with a multifactorial pathology involving genetic predisposition, epigenetic mechanisms, and environmental factors. Recent studies indicate a significant regulatory role of non-coding RNAs in the disease, particularly microRNAs and long non-coding RNAs. Limited data is available on the genetic variability of non-coding RNAs in SS susceptibility, highlighting the need for further research to understand underlying pathogenic processes and develop targeted therapies.