期刊
FRONTIERS IN PHYSIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2021.680213
关键词
atrial natriuretic peptide; nephroprotection; kidney; natriuresis; antioxidant
类别
资金
- UBACYT [20020170100621BA]
- PICT [2018-01105]
- Fundacion H.A. Barcelo
Atrial natriuretic peptide, part of the natriuretic peptide family, has natriuretic, diuretic, and vasodilator effects that oppose the renin-angiotensin system. It also exerts nephroprotective effects due to its antioxidant and anti-inflammatory properties, making it a beneficial agent against acute and chronic kidney diseases.
Atrial natriuretic peptide belongs to the family of natriuretic peptides, a system with natriuretic, diuretic, and vasodilator effects that opposes to renin-angiotensin system. In addition to its classic actions, atrial natriuretic peptide exerts a nephroprotective effect given its antioxidant and anti-inflammatory properties, turning it as a beneficial agent against acute and chronic kidney diseases. This minireview describes the most relevant aspects of atrial natriuretic peptide in the kidney, including its renal synthesis, physiological actions through specific receptors, the importance of its metabolism, and its potential use in different pathological scenarios.
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