期刊
FRONTIERS IN PHARMACOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2021.688490
关键词
Alzeheimer's disease; ginseng (Panax ginseng C; A; Meyer); ginsenosidase; gintonin; neuroprotection
资金
- National Key Research and Development Program of China [2017YFC1702103]
- National Natural Science Foundation of China [U19A2013]
- Science and Technology Development Plan Project of Jilin Province [20190101010JH, 202002053JC]
This review summarizes the effects and mechanisms of Panax ginseng in Alzheimer's disease, as well as its potential use in the prevention and treatment of AD.
Alzheimer's disease (AD), a neurodegenerative disorder, is a major health concern in the increasingly aged population worldwide. Currently, no clinically effective drug can halt the progression of AD. Panax ginseng C.A. Mey. is a well-known medicinal plant that contains ginsenosides, gintonin, and other components and has neuroprotective effects against a series of pathological cascades in AD, including beta-amyloid formation, neuroinflammation, oxidative stress, and mitochondrial dysfunction. In this review, we summarize the effects and mechanisms of these major components and formulas containing P. ginseng in neuronal cells and animal models. Moreover, clinical findings regarding the prevention and treatment of AD with P. ginseng or its formulas are discussed. This review can provide new insights into the possible use of ginseng in the prevention and treatment of AD.
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