Sirtuin 2 (SIRT2): Confusing Roles in the Pathophysiology of Neurological Disorders

As a type of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylases, sirtuin 2 (SIRT2) is predominantly found in the cytoplasm of cells in the central nervous system (CNS), suggesting its potential role in neurological disorders. Though SIRT2 is generally acknowledged to accelerate the development of neurological pathologies, it protects the brain from deterioration in certain circumstances. This review summarized the complex roles SIRT2 plays in the pathophysiology of diverse neurological disorders, compared and analyzed the discrete roles of SIRT2 in different conditions, and provided possible explanations for its paradoxical functions. In the future, the rapid growth in SIRT2 research may clarify its impacts on neurological disorders and develop therapeutic strategies targeting this protein.

Automated summary

SIRT2, as a NAD(+)-dependent deacetylase, is mainly located in the cytoplasm of CNS cells, indicating its potential role in neurological disorders. While it is generally believed to accelerate the development of neurological pathologies, it can also protect the brain in certain circumstances. This review summarizes the complex roles SIRT2 plays in various neurological disorders, comparing and analyzing its distinct roles in different conditions, and providing possible explanations for its paradoxical functions.