4.6 Article

Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension

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FRONTIERS IN NEUROSCIENCE
卷 15, 期 -, 页码 -

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FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2021.690919

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hydrogen sulfide; hypertension; microglia; neuroinflammation; paraventricular nucleus; microbiota; angiotensin

资金

  1. TUBITAK [2214-A, AWD07186, R21AT010192]

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Chronic infusion of sodium hydrosulfide was found to alleviate the effects of Ang II-induced hypertension in rats and impact microglia in PVN. This suggests that central H2S may alleviate rodent hypertension independently of circulating H2S via effects on the autonomic nervous system and PVN microglia.
Hydrogen sulfide (H2S) is a gaseous signaling molecule with neuromodulatory, anti-inflammatory, and anti-hypertensive effects. Here, we investigate whether chronic intracerebroventricular (ICV) infusion of sodium hydrosulfide (NaHS), an H2S donor, can alleviate angiotensin II (Ang II)-induced hypertension (HTN), improve autonomic function, and impact microglia in the paraventricular nucleus (PVN) of the hypothalamus, a brain region associated with autonomic control of blood pressure (BP) and neuroinflammation in HTN. Chronic delivery of Ang II (200 ng/kg/min, subcutaneous) for 4 weeks produced a typical increase in BP and sympathetic drive and elevated the number of ionized calcium binding adaptor molecule 1-positive (Iba1(+)) cells in the PVN of male, Sprague-Dawley rats. ICV co-infusion of NaHS (at 30 and/or 60 nmol/h) significantly attenuated these effects of Ang II. Ang II also increased the abundance of cecal Deltaproteobacteria and Desulfovibrionales, among others, which was prevented by ICV NaHS co-infusion at 30 and 60 nmol/h. We observed no differences in circulating H2S between the groups. Our results suggest that central H2S may alleviate rodent HTN independently from circulating H2S via effects on autonomic nervous system and PVN microglia.

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