期刊
FRONTIERS IN NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2021.673440
关键词
atherosclerosis; vascular disease; atherosclerosis biomarkers; hypoperfusion; common risk factors
资金
- National Natural Science Foundation of China [81660751, 81660151, 82060661]
- Key Research and Jiangxi Provincial Natural Science Foundation of China [20171BAB205085]
- Nanchang University Student Innovation and Entrepreneurship Training Program [20190402240]
This review summarizes AS biomarkers as predictors for VD for the first time and describes the direct mechanisms of AS causing VD from multiple aspects. The data indicate that AS is not only a pathogenic factor but also a comorbidity in VD.
Vascular dementia (VD), a cerebrovascular disease which causes cognitive impairment, is one of the significant factors that affects the quality of senectitude. Atherosclerosis (AS) is a chronic inflammatory syndrome and closely associated with VD. Analyzing the role of AS in VD contribute greatly to its early detection and prevention, but their relationship has not been integrated into a complete network. This review summarizes AS biomarkers as VD predictors for the first time and describes the direct mechanisms of AS causing VD from five aspects: vascular morphogenesis, hemodynamic change, neurovascular unit damage (NVU), oxidative stress, and microRNA (miRNA). Finally, it discriminates the relationship between AS and VD in common risk factors which can be disease or some molecules. In particular, these data imply that the role of AS in VD is not only a pathogenic factor but also a comorbidity in VD. This review aims to bring new ideas for the prediction and treatment of VD.
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