期刊
FRONTIERS IN NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2021.730417
关键词
prokineticin receptor; GPCR; MRAP2; trafficking; glycosylation
资金
- NIH [RO3TR002838]
This study identified two N-linked glycosylation sites within the N-terminal region of PKR2 and demonstrated that glycosylation at position 27 is crucial for its plasma membrane localization and signaling. Additionally, glycosylation at position 7 was found to decrease PKR2 signaling through G alpha(s) without affecting G alpha(q/)(11) signaling.
Prokineticin receptors are GPCRs involved in several physiological processes including the regulation of energy homeostasis, nociception, and reproductive function. PKRs are inhibited by the endogenous accessory protein MRAP2 which prevents them from trafficking to the plasma membrane. Very little is known about the importance of post-translational modification of PKRs and their role in receptor trafficking and signaling. Here we identify 2 N-linked glycosylation sites within the N-terminal region of PKR2 and demonstrate that glycosylation of PKR2 at position 27 is important for its plasma membrane localization and signaling. Additionally, we show that glycosylation at position 7 results in a decrease in PKR2 signaling through G alpha(s) without impairing G alpha(q/)(11) signaling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据