期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2021.714768
关键词
long non-coding RNAs; central nervous system; neuronal development; neurological disorders; gene regulation
资金
- VLAIO, the Flemish Agency for Innovation and Entrepeneurship (Vlaams Agentschap Innoveren en Ondernemen)
- VLAIO [HBC.2018.2290, HBC.2020.3236]
- VIB-KU Leuven
- MRC [UKDRI-1004] Funding Source: UKRI
Recent advances in RNA sequencing technologies have revealed the significance of long non-coding RNAs (lncRNAs) in modulating protein-coding gene expression, especially in the central nervous system. Therefore, lncRNAs are gaining attention as potential novel therapeutic targets for brain disorders.
Recent advances in RNA sequencing technologies helped to uncover the existence of tens of thousands of long non-coding RNAs (lncRNAs) that arise from the dark matter of the genome. These lncRNAs were originally thought to be transcriptional noise but an increasing number of studies demonstrate that these transcripts can modulate protein-coding gene expression by a wide variety of transcriptional and post-transcriptional mechanisms. The spatiotemporal regulation of lncRNA expression is particularly evident in the central nervous system, suggesting that they may directly contribute to specific brain processes, including neurogenesis and cellular homeostasis. Not surprisingly, lncRNAs are therefore gaining attention as putative novel therapeutic targets for disorders of the brain. In this review, we summarize the recent insights into the functions of lncRNAs in the brain, their role in neuronal maintenance, and their potential contribution to disease. We conclude this review by postulating how these RNA molecules can be targeted for the treatment of yet incurable neurological disorders.
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