期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 14, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2021.720371
关键词
Rac1; long term potentiation; PI3K; LIMK; PKC?/?; PKM zeta
资金
- Project of the Foundation of National Natural Science of China [32030051, 31970956]
Rac1 activation has opposite effects on the induction and maintenance of LTP in the hippocampus, modulating different signaling pathways during the different stages; activation of Rac1 during LTP induction leads to PKC ι/λ activation, while activation of Rac1 during LTP maintenance leads to PKM zeta inhibition.
Rac1 is a small GTPase of the Rho family. A previous study showed that the activation of Rac1 had an opposing effect on induction and maintenance of long-term potentiation (LTP) in the hippocampus. However, the molecular mechanism underlying this opposing effect remains to be addressed. In the present work, we find that the activation of Rac1 during the induction of LTP leads to an activation of PKC iota/lambda by phosphatidylinositol-3-kinase (PI3K), whereas the activation of Rac1 during the maintenance of LTP leads to the inhibition of PKM zeta by LIM_kinase (LIMK) in the hippocampus. This result suggests that during different stages of LTP, the activation of Rac1 can modulate different signaling pathways, which leads to an opposing effect on the induction and maintenance of LTP in the hippocampus.
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