Colchicine in the Management of Acute and Chronic Coronary Artery Disease

Purpose of Review Inflammation is involved in the initiation, progression, and destabilization of atherosclerosis. Anti-inflammatory strategies aimed at reducing residual cardiovascular (CV) risk have gained increasing interest in addition to the traditional management of risk factors. Colchicine is a potent anti-inflammatory therapy that affects the inflammasome and other targets. We will herein review the most recent evidence regarding the usefulness of colchicine in patients with coronary artery disease (CAD). Recent Findings Colchicine has recently been repurposed from its traditional use to a number of CV indications. The landmark COLCOT and LoDoCo2 trials have demonstrated that long-term use of colchicine was associated with a reduced rate of CV events in both acute and chronic presentations of CAD, with an overall good safety profile. Colchicine is emerging as a valuable, safe, and cost-effective therapy in addition to standard of care for the prevention of atherothrombotic events in CAD.

Automated summary

Inflammation plays a crucial role in atherosclerosis, making anti-inflammatory strategies important for reducing cardiovascular risk. Colchicine, a potent anti-inflammatory therapy, has shown positive effects and safety in patients with coronary artery disease, emerging as a valuable treatment option.