4.3 Review

Mechanisms Driving Immune-Related Adverse Events in Cancer Patients Treated with Immune Checkpoint Inhibitors

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, General & Internal

Immunosuppressive B cells expressing PD-1/PD-L1 in solid tumors: a mini review

X. Sun et al.

Summary: This review discusses the expression of PD-1/PD-L1 on B cells and their immunosuppressive role in solid tumors, aiming to explore the potential for diagnostic tools and new therapies involving this unique group of cells.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2022)

Article Oncology

Tofacitinib for treatment in immune-mediated myocarditis: The first reported cases

Yun Liu et al.

Summary: Immune checkpoint inhibitors have shown significant clinical benefits in treating advanced cancer, but they can also lead to severe side effects such as myocarditis. This case report describes two patients with ICI-associated myocarditis who were successfully treated with oral tofacitinib, providing a new option for refractory myocarditis or other immune-related adverse events in clinical practice.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2021)

Review Cell Biology

The microbiome in inflammatory bowel diseases: from pathogenesis to therapy

Sheng Liu et al.

Summary: Inflammatory bowel disease (IBD) is a global disease with accelerating incidence worldwide, and dysbiosis of gut microbiota has been consistently associated with IBD. Some alterations in microbiome may have protective or causative effects on IBD. Therapeutic approaches targeting microbiome are a promising strategy for alleviating and curing IBD.

PROTEIN & CELL (2021)

Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

Article Oncology

Management of Immunotherapy-Related Toxicities, Version 1.2020 Featured Updates to the NCCN Guidelines

John A. Thompson et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

Review Gastroenterology & Hepatology

Gut microbiota-derived metabolites as key actors in inflammatory bowel disease

Aonghus Lavelle et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2020)

Review Cell Biology

Signaling networks in immunometabolism

Jordy Saravia et al.

CELL RESEARCH (2020)

Article Cardiac & Cardiovascular Systems

Immune Checkpoint Inhibitor Myocarditis: Pathophysiological Characteristics, Diagnosis, and Treatment

Nicolas Palaskas et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

Review Biochemistry & Molecular Biology

The Gut Microbiota: Emerging Evidence in Autoimmune Diseases

Xuan Zhang et al.

TRENDS IN MOLECULAR MEDICINE (2020)

Article Biochemistry & Molecular Biology

Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy

Adrienne M. Luoma et al.

Article Oncology

Immune checkpoint inhibitor-associated celiac disease

Yousef Badran et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Article Clinical Neurology

Neurologic autoimmunity and immune checkpoint inhibitors

Elia Sechi et al.

NEUROLOGY (2020)

Review Biochemistry & Molecular Biology

Role of Human Leukocyte Antigen System as A Predictive Biomarker for Checkpoint-Based Immunotherapy in Cancer Patients

Francesco Sabbatino et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Cardiac & Cardiovascular Systems

Decreased Absolute Lymphocyte Count and Increased Neutrophil/Lymphocyte Ratio With Immune Checkpoint Inhibitor-Associated Myocarditis

Zsofia D. Drobni et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)

Review Immunology

Metabolic coordination of T cell quiescence and activation

Nicole M. Chapman et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Review Immunology

The pathogenicity of Th17 cells in autoimmune diseases

Keiko Yasuda et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

Article Oncology

Treatment Outcomes of Immune-Related Cutaneous Adverse Events

Gregory S. Phillips et al.

JOURNAL OF CLINICAL ONCOLOGY (2019)

Article Oncology

Myasthenia Gravis Induced by Immune Checkpoint Inhibitors

Ondine Becquart et al.

JOURNAL OF IMMUNOTHERAPY (2019)

Review Medicine, General & Internal

Neurologic Autoimmunity in the Era of Checkpoint Inhibitor Cancer Immunotherapy

Anastasia Zekeridou et al.

MAYO CLINIC PROCEEDINGS (2019)

Letter Medicine, General & Internal

Abatacept for Severe Immune Checkpoint Inhibitor-Associated Myocarditis

Joe-Elie Salem et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Immunology

Innate Lymphoid Cells: Expression of PD-1 and Other Checkpoints in Normal and Pathological Conditions

Francesca Romana Merlotti et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Endocrinology & Metabolism

Hypophysitis secondary to nivolumab and pembrolizumab is a clinical entity distinct from ipilimumab-associated hypophysitis

Alexander Faje et al.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2019)

Article Medicine, Research & Experimental

The alveolar immune cell landscape is dysregulated in checkpoint inhibitor pneumonitis

Karthik Suresh et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Editorial Material Biotechnology & Applied Microbiology

Immuno-oncology drug development goes global

Jia Xin Yu et al.

NATURE REVIEWS DRUG DISCOVERY (2019)

Article Oncology

A case of checkpoint inhibitor-induced celiac disease

Dana Alsaadi et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2019)

Review Biochemistry & Molecular Biology

Cytokines in Inflammatory Disease

Shinwan Kany et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Biochemistry & Molecular Biology

Novel immune checkpoint targets: moving beyond PD-1 and CTLA-4

Shuang Qin et al.

MOLECULAR CANCER (2019)

Article Multidisciplinary Sciences

Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation

Khashayar Esfahani et al.

NATURE COMMUNICATIONS (2019)

Article Immunology

Fine-Tuning Cytokine Signals

Jian-Xin Lin et al.

Annual Review of Immunology (2019)

Article Oncology

Autoantibody Development under Treatment with Immune-Checkpoint Inhibitors

Emma C. de Moel et al.

CANCER IMMUNOLOGY RESEARCH (2019)

Article Endocrinology & Metabolism

Clinical heterogeneity of hypophysitis secondary to PD-1/PD-L1 blockade: insights from four cases

Isabella Lupi et al.

ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS (2019)

Review Immunology

Cytokine-mediated communication: a quantitative appraisal of immune complexity

Gregoire Altan-Bonnet et al.

NATURE REVIEWS IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients

V. Gopalakrishnan et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

Review Dermatology

A review of bullous pemphigoid associated with PD-1 and PD-L1 inhibitors

Adriana T. Lopez et al.

INTERNATIONAL JOURNAL OF DERMATOLOGY (2018)

Article Medicine, Research & Experimental

Early B cell changes predict autoimmunity following combination immune checkpoint blockade

Rituparna Das et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Cardiac & Cardiovascular Systems

Myocarditis in Patients Treated With Immune Checkpoint Inhibitors

Syed S. Mahmood et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)

Article Medicine, Research & Experimental

Contribution of NK cells to immunotherapy mediated by PD-1/PD-L1 blockade

Joy Hsu et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Oncology

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

Spencer C. Wei et al.

CANCER DISCOVERY (2018)

Article Biochemistry & Molecular Biology

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

Yinghong Wang et al.

NATURE MEDICINE (2018)

Review Biochemistry & Molecular Biology

Immune checkpoint inhibitors: recent progress and potential biomarkers

Pramod Darvin et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2018)

Article Oncology

Pneumonitis in Patients Treated With Anti-Programmed Death-1/Programmed Death Ligand 1 Therapy

Jarushka Naidoo et al.

JOURNAL OF CLINICAL ONCOLOGY (2017)

Article Multidisciplinary Sciences

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target

Robert T. Manguso et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Is autoimmunity the Achilles' heel of cancer immunotherapy?

Carl H. June et al.

NATURE MEDICINE (2017)

Article Medicine, General & Internal

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

J. D. Wolchok et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Letter Medicine, General & Internal

Reversal of Autoimmune Toxicity and Loss of Tumor Response by Interleukin-17 Blockade

Khashayar Esfahani et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Cell Biology

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Angel Garcia-Diaz et al.

CELL REPORTS (2017)

Review Cell Biology

The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells

Farhad Seif et al.

CELL COMMUNICATION AND SIGNALING (2017)

Article Medicine, General & Internal

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

Douglas B. dbj Johnson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Multidisciplinary Sciences

Clonal expansion of CD8 T cells in the systemic circulation precedes development of ipilimumab-induced toxicities

Sumit K. Subudhi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Multidisciplinary Sciences

Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

Krista Dubin et al.

NATURE COMMUNICATIONS (2016)

Review Immunology

Gut microbiota, metabolites and host immunity

Michelle G. Rooks et al.

NATURE REVIEWS IMMUNOLOGY (2016)

Article Medicine, Research & Experimental

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and aging

Andras Perl

COMPANION DIAGNOSTICS: FROM BIOMARKER IDENTIFICATION TO MARKET ENTRY (2015)

Review Immunology

Innate Immune Recognition of Cancer

Seng-Ryong Woo et al.

ANNUAL REVIEW OF IMMUNOLOGY VOL 33 (2015)

Review Medicine, Research & Experimental

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

John J. O'Shea et al.

ANNUAL REVIEW OF MEDICINE, VOL 66 (2015)

Review Immunology

The expanding family of regulatory B cells

Claudia Mauri et al.

INTERNATIONAL IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Marie Vetizou et al.

SCIENCE (2015)

Review Multidisciplinary Sciences

The future of immune checkpoint therapy

Padmanee Sharma et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

PD-L1(hi) B cells are critical regulators of humoral immunity

Adnan R. Khan et al.

NATURE COMMUNICATIONS (2015)

Review Immunology

mTOR signaling, Tregs and immune modulation

Nicole M. Chapman et al.

IMMUNOTHERAPY (2014)

Article Multidisciplinary Sciences

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

Hye Sun Kuehn et al.

SCIENCE (2014)

Review Immunology

Molecular mechanisms of T cell co-stimulation and co-inhibition

Lieping Chen et al.

NATURE REVIEWS IMMUNOLOGY (2013)

Article Medicine, General & Internal

Safety, Activity, and Immune Correlates of Anti-PD-1 Antibody in Cancer

Suzanne L. Topalian et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Oncology

The blockade of immune checkpoints in cancer immunotherapy

Drew M. Pardoll

NATURE REVIEWS CANCER (2012)

Article Medicine, General & Internal

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

F. Stephen Hodi et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Pediatrics

The Treg/Th17 Cell Balance: A New Paradigm for Autoimmunity

Eli M. Eisenstein et al.

PEDIATRIC RESEARCH (2009)

Review Oncology

Cytokines and their relationship to the symptoms and outcome of cancer

Bostjan Seruga et al.

NATURE REVIEWS CANCER (2008)

Article Multidisciplinary Sciences

Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

H Nishimura et al.

SCIENCE (2001)