期刊
CATALYSTS
卷 11, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/catal11060712
关键词
ketimine Mannich; ketimine allylation; aza-Morita-Baylis-Hillman; asymmetric catalysis; alpha-tertiary amine; beta-amino carbonyl
资金
- National Institute of Health [1R15 GM139087-01]
This review discusses the application and challenges of catalytic enantioselective ketimine Mannich and related reactions in synthesizing chiral building blocks. Various approaches have been developed to overcome the adverse properties of ketimines in these transformations.
The catalytic enantioselective ketimine Mannich and its related reactions provide direct access to chiral building blocks bearing an alpha-tertiary amine stereogenic center, a ubiquitous structural motif in nature. Although ketimines are often viewed as challenging electrophiles, various approaches/strategies to circumvent or overcome the adverse properties of ketimines have been developed for these transformations. This review showcases the selected examples that highlight the benefits and utilities of various ketimines and remaining challenges associated with them in the context of Mannich, allylation, and aza-Morita-Baylis-Hillman reactions as well as their variants.
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