期刊
CATALYSTS
卷 11, 期 7, 页码 -出版社
MDPI
DOI: 10.3390/catal11070825
关键词
tunable Bronsted acidic ionic liquid; O-acetylation; O-trimethylsilylation; recycle; trimethylsilyl acetate; HMDS
资金
- Ministry of Science and Technology in Taiwan [MOST 108-2113-M-005-021, MOST 110-2113-M-005-017]
- National Chung Hsing University
This report presents a novel acetyl reagent and O-trimethylsilylation reaction for alcohols, catalyzed by TBAILs, achieving efficient acetylation protection reactions at room temperature. The TBAILs catalyst can be easily recovered and recycled multiple times through a simple process after the reaction.
This report discloses a mild and efficient O-acetylation using easily accessible TMSOAc as a novel acetyl reagent and O-trimethylsilylation using HMDS for various alcohols catalyzed by tunable Bronsted acidic ionic liquids (TBAILs). Imidazolium-based TBAILs were prepared by a two-step atom-economic reaction and acidities measured by using UV-visible spectroscopy. Both protections for alcohols were accomplished at room temperature with good to excellent yields, while the products and TBAILs were separated by simple work-up for O-silylation and column chromatography for O-acetylation. Notably, with the simple post-process, TBAILs catalyst in this solvent free method easily recovered and recycled several times without significant degradation.
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