期刊
CANCER MEDICINE
卷 10, 期 16, 页码 5395-5404出版社
WILEY
DOI: 10.1002/cam4.3573
关键词
hepatitis C; carcinoma; hepatocellular; inflammation; neutrophils; lymphocytes
类别
资金
- United States Department of Defense [CA160741]
Inflammation and the immune system play a significant role in the prognosis of hepatocellular carcinoma in Western patients with chronic viral hepatitis, with the neutrophil-to-lymphocyte ratio (NLR) potentially serving as a prognostic biomarker.
Background Inflammation and the immune system significantly impact the development, progression, and treatment response of hepatocellular carcinoma (HCC). This retrospective study investigated the neutrophil-to-lymphocyte ratio (NLR) as a prognostic biomarker in Western patients with HCC in the setting of chronic viral hepatitis. Methods Patients diagnosed with HCC from 2005 to 2016 were selected from a tertiary care institution. NLR was calculated within 30 days prior to treatment and dichotomized at the median. Kaplan-Meier overall survival (OS) curves and Cox hazard proportional models were utilized. Tumor and liver reserve parameters were included in multivariable analyses (MVA). Results A total of 581 patients met inclusion criteria (median age 61.0 yr; 78.3% male; 66.3% Caucasian) with median OS = 34.9 mo. 371 patients (63.9%) had viral hepatitis, of which 350 had hepatitis C (94.3%). The low-NLR group (
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