期刊
ADVANCED MATERIALS INTERFACES
卷 8, 期 20, 页码 -出版社
WILEY
DOI: 10.1002/admi.202100518
关键词
multimodality imaging; nanocomposite coatings; optical fibers; quantum dots; ultrasound imaging
资金
- Engineering and Physical Sciences Research Council (EPSRC) [EP/S513726/1]
- EPSRC UKRI Innovation Fellowship [EP/S001506/1]
- Johnson Matthey PLC [JM11372]
- Wellcome Trust [WT101957]
- Royal Academy of Engineering under the Research Fellowship Scheme
- European Research Council [741149]
- Centre for Doctoral Training in Molecular Modelling and Material's Science [EP/P020194]
- Surface Measurement Systems Ltd.
- Ramsay Memorial Trust
- Royal Commission
- EPSRC [EP/M015157/1]
- EPSRC [EP/M015157/1] Funding Source: UKRI
Dual-modality imaging using complementary modalities, such as all-optical ultrasound and photoacoustic imaging, is well-suited for guiding minimally invasive surgical procedures. Quantum dots, a promising material for these devices, provide wavelength-selective optical absorption for improved imaging capabilities.
Dual-modality imaging employing complementary modalities, such as all-optical ultrasound and photoacoustic imaging, is emerging as a well-suited technique for guiding minimally invasive surgical procedures. Quantum dots are a promising material for use in these dual-modality imaging devices as they can provide wavelength-selective optical absorption. The first quantum dot nanocomposite engineered for co-registered laser-generated ultrasound and photoacoustic imaging is presented. The nanocomposites developed, comprising CuInS2 quantum dots and medical-grade polydimethylsiloxane (CIS-PDMS), are applied onto the distal ends of miniature optical fibers. The films exhibit wavelength-selective optical properties, with high optical absorption (> 90%) at 532 nm for ultrasound generation, and low optical absorption (< 5%) at near-infrared wavelengths greater than 700 nm. Under pulsed laser irradiation, the CIS-PDMS films generate ultrasound with pressures exceeding 3.5 MPa, with a corresponding bandwidth of 18 MHz. An ultrasound transducer is fabricated by pairing the coated optical fiber with a Fabry-Perot (FP) fiber optic sensor. The wavelength-selective nature of the film is exploited to enable co-registered all-optical ultrasound and photoacoustic imaging of an ink-filled tube phantom. This work demonstrates the potential for quantum dots as wavelength-selective absorbers for all-optical ultrasound generation.
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