4.7 Article

Ventromedial prefrontal cortex/anterior cingulate cortex Glx, glutamate, and GABA levels in medication-free major depressive disorder

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Clinical Neurology

Ketamine and Serotonergic Psychedelics: Common Mechanisms Underlying the Effects of Rapid-Acting Antidepressants

Bashkim Kadriu et al.

Summary: Ketamine and serotonergic psychedelics may share a common mechanism in generating rapid neuroplastic effects and affecting cortical network activity that lead to antidepressant efficacy. Despite some similarities, the connection between the psychoactive component and antidepressant efficacy of these drugs remains unclear and requires further research. The prototypic nature of ketamine research and recent progress in this area suggest a promising platform for investigating new classes of rapid-acting antidepressants.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2021)

Article Clinical Neurology

Sex differences in the association between symptom profiles and cognitive functioning in patients with depressive disorder

Shuai Zhao et al.

Summary: The study found significant differences in the association between symptom profiles and cognitive impairment in male and female patients with depressive disorder. Female patients performed better in information processing speed, while different symptom profiles were independently associated with specific cognitive functions in male and female patients.

JOURNAL OF AFFECTIVE DISORDERS (2021)

Article Behavioral Sciences

Association Between Anterior Cingulate Cortex Neurochemical Profile and Clinical Remission After Electroconvulsive Treatment in Major Depressive Disorder A Longitudinal 1H Magnetic Resonance Spectroscopy Study

Cagatay Ermis et al.

Summary: This study assessed the neurochemical profile of patients with MDD before and after ECT, finding that Glx levels could be a predictor of remission. Larger studies should further explore the neurochemical correlates of ECT in MDD.

JOURNAL OF ECT (2021)

Article Psychiatry

Association of Age, Antipsychotic Medication, and Symptom Severity in Schizophrenia With Proton Magnetic Resonance Spectroscopy Brain Glutamate Level A Mega-analysis of Individual Participant-Level Data

Kate Merritt et al.

Summary: The study suggests that lower brain glutamate levels in patients with schizophrenia may be associated with exposure to antipsychotic medication rather than age-related decline. Higher brain glutamate levels may act as a biomarker of illness severity in schizophrenia.

JAMA PSYCHIATRY (2021)

Article Neurosciences

Characteristics Associated with Depression Severity in 270 Juveniles in a Major Depressive Episode

Giulia Serra et al.

Summary: This study analyzed factors associated with depression severity in 270 juveniles aged 6-18 who were diagnosed with major depressive episode. It was found that greater depression severity was associated with female sex, diagnosis of major depressive disorder (MDD), and some manic symptoms. Careful assessment of manic/psychotic symptoms is crucial in evaluating juvenile depression and should be considered in treatment planning.

BRAIN SCIENCES (2021)

Article Psychiatry

Relationship of Brain Glutamate Response to D-Cycloserine and Lurasidone to Antidepressant Response in Bipolar Depression: A Pilot Study

Zhengchao Dong et al.

Summary: This study assessed the impact of D-cycloserine combined with lurasidone on glutamate and Glx in bipolar disorder depression, finding that the change in glutamate levels correlated negatively with improvement in depression severity. These preliminary pilot results suggest a link between antidepressant effects and decreased glutamate levels by NMDAR antagonists.

FRONTIERS IN PSYCHIATRY (2021)

Review Radiology, Nuclear Medicine & Medical Imaging

Methodological consensus on clinical proton MRS of the brain: Review and recommendations

Martin Wilson et al.

MAGNETIC RESONANCE IN MEDICINE (2019)

Article Neurosciences

A Human Depression Circuit Derived From Focal Brain Lesions

Jaya L. Padmanabhan et al.

BIOLOGICAL PSYCHIATRY (2019)

Article Medicine, General & Internal

Trial of SAGE-217 in Patients with Major Depressive Disorder

Handan Gunduz-Bruce et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Review Behavioral Sciences

Prefrontal excitatory/inhibitory balance in stress and emotional disorders: Evidence for over-inhibition

Chloe E. Page et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2019)

Article Endocrinology & Metabolism

Neurochemical sex differences in adult ADHD patients: an MRS study

Dominique Endres et al.

Biology of Sex Differences (2019)

Article Genetics & Heredity

A pilot integrative genomics study of GABA and glutamate neurotransmitter systems in suicide, suicidal behavior, and major depressive disorder

Honglei Yin et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2016)

Review Clinical Neurology

Cortical thickness in bipolar disorder: a systematic review

Lindsay C. Hanford et al.

BIPOLAR DISORDERS (2016)

Article Neurosciences

On the Effect of Sex on Prefrontal and Cerebellar Neurometabolites in Healthy Adults: An MRS Study

Dominique Endres et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2016)

Letter Psychology, Clinical

Single-Dose Ketamine Followed by Daily D-Cycloserine in Treatment-Resistant Bipolar Depression

Joshua T. Kantrowitz et al.

JOURNAL OF CLINICAL PSYCHIATRY (2015)

Article Biochemistry & Molecular Biology

Sex differences in glutamate receptor gene expression in major depression and suicide

A. L. Gray et al.

MOLECULAR PSYCHIATRY (2015)

Article Psychology, Clinical

ANXIETY IN MAJOR DEPRESSION AND CEREBROSPINAL FLUID FREE GAMMA-AMINOBUTYRIC ACID

J. John Mann et al.

DEPRESSION AND ANXIETY (2014)

Article Clinical Neurology

Gender differences in major depressive disorder: Results from the Netherlands study of depression and anxiety

Jerome J. J. Schuch et al.

JOURNAL OF AFFECTIVE DISORDERS (2014)

Article Clinical Neurology

Could glutamate spectroscopy differentiate bipolar depression from unipolar?

Matthew J. Taylor

JOURNAL OF AFFECTIVE DISORDERS (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Macromolecule-suppressed GABA-edited magnetic resonance spectroscopy at 3T

Richard A. E. Edden et al.

MAGNETIC RESONANCE IN MEDICINE (2012)

Article Neurosciences

Increased Glutamate Levels in the Medial Prefrontal Cortex in Patients with Postpartum Depression

Alyssa M. McEwen et al.

NEUROPSYCHOPHARMACOLOGY (2012)

Article Radiology, Nuclear Medicine & Medical Imaging

Effects of age and sex on brain glutamate and other metabolites

Linda Chang et al.

MAGNETIC RESONANCE IMAGING (2009)

Article Clinical Neurology

Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients

Zubin Bhagwagar et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2008)

Article Radiology, Nuclear Medicine & Medical Imaging

Measurement of brain glutamate using TE-averaged PRESS at 3T

R Hurd et al.

MAGNETIC RESONANCE IN MEDICINE (2004)

Review Biochemistry & Molecular Biology

Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments

JH Krystal et al.

MOLECULAR PSYCHIATRY (2002)