期刊
NANO ENERGY
卷 85, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.nanoen.2021.106006
关键词
Neural plasticity; Self-powered wearable devices; Piezoelectric effect; Long-term potentiation; Long-term depression; Bidirectional modulation
类别
资金
- National Key Research and Development Program of China [2018YFA0701405]
- National Natural Science Foundation of China [31671101, 32070985, 11674048]
- ShenzhenHong Kong Institute of Brain ScienceShenzhen Fundamental Research Institutions
- Sichuan Science and Technology Program [2020JDJQ0026]
The study introduces a self-powered neural stimulation system that harvests energy from body motion to perform bidirectional modulation of neural plasticity, successfully delivering neural plasticity changes in the mouse hippocampus. This system, based on flexible materials and energy-harvesting technology, can be used for modulation of neural plasticity, plasticity-based therapy, or brain-machine interactions.
Devices to perform neural stimulation rely on batteries or permanent power outlet for power supply and delivery of electrical stimulation. Bulky system frame and inflexible component design are the limiting factors to improve portability and compatibility. Here, we report design and use of self-powered neural stimulation that can harvest energy from body motion and perform bidirectional modulation of neural plasticity. The system builds on flexible materials and integrates piezoelectric nanogenerator for energy-harvesting, signal modulation component for dual-modality output of stimulation pulses and implantable electrodes for delivery of stimulation to the neural tissue. When the neural stimulation is delivered in vivo in the mouse hippocampus, two forms of neural plasticity changes, long-term potentiation (LTP) and long-term depression (LTD), have been successfully delivered. The self-powered system demonstrates that integrated neural stimulation design driven by energy harvested from biological motions in the environment is suitable for modulation of neural plasticity, plasticity-based therapy or brain-machine interactions.
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