期刊
GENOME RESEARCH
卷 26, 期 8, 页码 1101-1109出版社
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gr.205245.116
关键词
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资金
- Health Innovation Challenge Fund [HICF-T5-342, WT098600]
- UK Department of Health
- Wellcome Trust
- Medical Research Council [G1100100/1]
- Wellcome Trust Sanger Institute [098051]
- MRC [G1100100] Funding Source: UKRI
- Medical Research Council [G1100100] Funding Source: researchfish
Serratia marcescens, a member of the Enterobacteriaceae family, is a Gram-negative bacterium responsible for a wide range of nosocomial infections. The emergence of multidrug-resistant strains is an increasing danger to public health. To design effective means to control the dissemination of S. marcescens, an in-depth analysis of the population structure and variation is required. Utilizing whole-genome sequencing, we characterized the population structure and variation, as well as the antimicrobial resistance determinants, of a systematic collection of antimicrobial-resistant S. marcescens associated with bloodstream infections in hospitals across the United Kingdom and Ireland between 2001 and 2011. Our results show that S. marcescens is a diverse species with a high level of genomic variation. However, the collection was largely composed of a limited number of clones that emerged from this diverse background within the past few decades. We identified potential recent transmissions of these clones, within and between hospitals, and showed that they have acquired antimicrobial resistance determinants for different beta-lactams, ciprofloxacin, and tetracyclines on multiple occasions. The expansion of these multi-drug-resistant clones suggests that the treatment of S. marcescens infections will become increasingly difficult in the future.
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