期刊
JOURNAL OF NANOBIOTECHNOLOGY
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12951-021-00932-2
关键词
Anti-PD-L1; Biomimetic black phosphorus quantum dots; Photothermal immunotherapy; Triple-negative breast cancer; Tumor recurrence and metastasis
资金
- National Natural Science Foundation of China [81402575]
This study developed a combined photothermal immunotherapy strategy using BBPQDs for TNBC treatment, showing enhanced antitumor activity compared to anti-PD-L1 monotherapy. The strategy effectively inhibits tumor recurrence and metastasis by reprogramming the tumor microenvironment and inducing immune memory against tumor rechallenge.
BackgroundTriple-negative breast cancer (TNBC) is a highly aggressive malignant disease with a high rate of recurrence and metastasis, few effective treatment options and poor prognosis. Here, we designed and constructed a combined photothermal immunotherapy strategy based on cancer cell membrane-coated biomimetic black phosphorus quantum dots (BBPQDs) for tumor-targeted photothermal therapy and anti-PD-L1 mediated immunotherapy.ResultsBBPQDs have good photothermal conversion efficiency and can efficiently target tumor cells through homologous targeting and tumor homing. Under near infrared irradiation, we found that BBPQDs kill tumors directly through photothermal effects and induce dendritic cells maturation. In vivo studies have confirmed that the combined photothermal immunotherapy strategy displays a stronger antitumor activity than anti-PD-L1 monotherapy. In addition, BBPQDs-mediated photothermal therapy in combination with anti-PD-L1 treatment inhibit tumor recurrence and metastasis by reprograming the immunosuppressive tumor microenvironment into an immune-active microenvironment, and promoting the local and systemic antitumor immune response. We further found that the combined photothermal immunotherapy strategy can produce an immune memory effect against tumor rechallenge.ConclusionsThis study provides a novel therapeutic strategy for inhibiting the recurrence and metastasis of TNBC, with broad application prospects.
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