期刊
JOURNAL OF NANOBIOTECHNOLOGY
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12951-021-01006-z
关键词
Prussian blue nanoparticles; Nanozyme; Reactive oxygen; nitrogen species scavenging; Acute kidney injury; Theranostics
资金
- National Natural Science Foundation of China [82071985]
- National Key R&D Program of China [2018YFA0704000]
- Basic Research Program of Shenzhen [JCYJ20180507182413022, JCYJ20170412111100742]
- Guangdong Province Natural Science Foundation of Major Basic Research and Cultivation Project [2018B030308003]
- Shenzhen Science and Technology Program [KQTD20190929172538530]
- Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China [161032]
In this study, ultrasmall Prussian blue nanozymes were synthesized as theranostics for AKI treatment, showing excellent performance in eliminating RONS and treating AKI, suggesting great potential for AKI management.
Background: Acute kidney injury (AKI) with high mortality rates is associated with an excess of reactive oxygen/nitrogen species (RONS) within kidney tissues. Recently, nanomedicine antioxidant therapy has been used to alleviate AKI. Herein, we synthesized ultrasmall Prussian blue nanozymes (PB NZs, 4.5 nm) as theranostic agents for magnetic resonance (MR)/photoacoustic (PA) dual-modal imaging guided AKI treatment. Results: PB NZs exhibited multi-enzyme mimetic abilities, promoting the effective elimination of RONS both in vitro and in vivo. Moreover, benefiting from their imaging contrast properties, the rapid renal accumulation of PB NZs was verified by in vivo PA/MR dual-modal imaging. Due to their excellent enrichment in the kidney and unique multi-enzyme mimetic abilities, ultrasmall PB NZs displayed superior AKI treatment efficacy compared with that of amifostine in two clinically relevant types of AKI induced murine models (either by rhabdomyolysis or cisplatin). Conclusion: Our findings suggested ultrasmall PB NZs, as nanozyme theranostics, have great potential for AKI management. Graphic abstract
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