期刊
GENOME BIOLOGY AND EVOLUTION
卷 8, 期 9, 页码 2928-2938出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evw199
关键词
Fusobacterium nucleatum; comparative genomics; F. nucleatum W1481
资金
- University of Malaya
- Ministry of Education, Malaysia under the High Impact Research (HIR) grant [UM.C/625/HIR/MOHE/CHAN-08]
- UMRG grant from University of Malaya
- Ministry of Education, Malaysia [RG541-13HTM]
Fusobacterium nucleatum is considered to be a key oral bacterium in recruiting periodontal pathogens into subgingival dental plaque. Currently F. nucleatum can be subdivided into five subspecies. Our previous genome analysis of F. nucleatum W1481 (referred to hereafter as W1481), isolated from an 8-mm periodontal pocket in a patient with chronic periodontitis, suggested the possibility of a new subspecies. To further investigate the biology and relationships of this possible subspecies with other known subspecies, we performed comparative analysis between W1481 and 35 genome sequences represented by the five known Fusobacterium subspecies. Our analyses suggest that W1481 is most likely anew F. nucleatum subspecies, supported by evidence from phylogenetic analyses and maximal unique matchindices(MUMi). Interestingly, we found a horizontally transferred W1481-specific genomic island harboring the tripartite ATP-independent (TRAP)-like transporter genes, suggesting this bacterium might have a high-affinity transport system for the C4-dicarboxylates malate, succinate, and fumarate. Moreover, we found virulence genes in the W1481 genome that may provide a strong defense mechanism which might enable it to colonize and survive within the host by evading immune surveillance. This comparative study provides better understanding of F. nucleatum and the basis for future functional work on this important pathogen.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据