期刊
GENOME BIOLOGY AND EVOLUTION
卷 8, 期 6, 页码 1812-1823出版社
OXFORD UNIV PRESS
DOI: 10.1093/gbe/evw113
关键词
ortholog; phylostratigraphy; LECA; LUCA
资金
- NIH [1F32GM112504-01A1]
- NIH
- NSF
- CPRIT
- ARO [61789-MA-MUR]
- Welch Foundation [F1515]
Correctly estimating the age of a gene or gene family is important for a variety of fields, including molecular evolution, comparative genomics, and phylogenetics, and increasingly for systems biology and disease genetics. However, most studies use only a point estimate of a gene's age, neglecting the substantial uncertainty involved in this estimation. Here, we characterize this uncertainty by investigating the effect of algorithm choice on gene-age inference and calculate consensus gene ages with attendant error distributions for a variety of model eukaryotes. We use 13 orthology inference algorithms to create gene-age datasets and then characterize the error around each age-call on a per-gene and per-algorithm basis. Systematic error was found to be a large factor in estimating gene age, suggesting that simple consensus algorithms are not enough to give a reliable point estimate. We also found that different sources of error can affect downstream analyses, such as gene ontology enrichment. Our consensus gene-age datasets, with associated error terms, are made fully available at so that researchers can propagate this uncertainty through their analyses (c)eneages arc)).
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据