期刊
FRONTIERS IN PLANT SCIENCE
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2021.596236
关键词
DNA methylation; DNA modification; environmental stress; epigenetics; gene regulation; 5-methylcytosine; N-6-methyladenine; plant growth
资金
- National Agricultural Science Fund [NASF/ABP-70161/2018-1]
- Indian Council of Agricultural Research, Government of India, New Delhi, India [18(3)/2018OP]
Epigenetic modifications in DNA bases and histone proteins play crucial roles in regulating gene expression and genome stability. The dynamics of DNA base methylation are mainly controlled by the activities of the writer/eraser, guided by ncRNA, and regulated by developmental/environmental cues. Recent advances in identifying ncRNA involved in de novo DNA methylation, DNA methylation proteins guiding DNA demethylase, and methylation monitoring sequences may help unravel some of the mysteries in epigenetic regulation.
Epigenetic modifications in DNA bases and histone proteins play important roles in the regulation of gene expression and genome stability. Chemical modification of DNA base (e.g., addition of a methyl group at the fifth carbon of cytosine residue) switches on/off the gene expression during developmental process and environmental stresses. The dynamics of DNA base methylation depends mainly on the activities of the writer/eraser guided by non-coding RNA (ncRNA) and regulated by the developmental/environmental cues. De novo DNA methylation and active demethylation activities control the methylation level and regulate the gene expression. Identification of ncRNA involved in de novo DNA methylation, increased DNA methylation proteins guiding DNA demethylase, and methylation monitoring sequence that helps maintaining a balance between DNA methylation and demethylation is the recent developments that may resolve some of the enigmas. Such discoveries provide a better understanding of the dynamics/functions of DNA base methylation and epigenetic regulation of growth, development, and stress tolerance in crop plants. Identification of epigenetic pathways in animals, their existence/orthologs in plants, and functional validation might improve future strategies for epigenome editing toward climate-resilient, sustainable agriculture in this era of global climate change. The present review discusses the dynamics of DNA methylation (cytosine/adenine) in plants, its functions in regulating gene expression under abiotic/biotic stresses, developmental processes, and genome stability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据